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KMID : 0371320070730020096
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Journal of the Korean Surgical Society
2007 Volume.73 No. 2 p.96 ~ p.102
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Characteristics of Late Recurrent Breast Cancers More than 5 Years after Primary Treatment
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Kim Hyun-Jin
Kang Soo-Hwan
Lee Soo-Jung
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Abstract
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Purpose: The conventional prognostic factors for breast cancer reflect the early short-term prognosis. However, many of these factors cannot predict the long-term prognosis accurately. Therefore, this study evaluated the characteristics of breast cancer that would indicate the development of delayed recurrences after primary treatment.
Methods: Eight hundred and forty nine female breast cancer patients were divided into two groups, an early recurrent (within 5 years) and a late recurrent group (after 5 years). Each conventional prognostic factor including the histological grade (HG), nuclear grade (NG), lympho-vascular invasion (LVI), status of hormonal receptor, p53 and c-erbB2 were compared to identify any factor that would show significant difference.
Results: The overall recurrence rate was 14.2% (121/849), which was significantly higher in patients with a high TNM stage, high HG and NG, positive LVI, negative receptor status and expression of p53 (P＜0.05). The mean disease free interval was 28.2 months. In the recurred patients, 90.1% (109/121) recurred within 5 years, and 9.9% (12/121) recurred after 5 years of treatment. There was a similar distribution of most prognostic factors in the two groups (P＞0.05). However, the positive rate of the hormonal receptor was significantly higher in the late recurrent group (P=0.019). All these factors, except for c-erbB2 over-expression, were independent prognostic factors for a recurrence within 5 years (P＜0.05) but the significance of these factors disappeared after that time (P＞0.05).
Conclusion: The positive hormone receptor of breast cancer is a good early prognostic factor that can also predict late recurrences. (J Korean Surg Soc 2007;73:96-102)
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KEYWORD
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Breast cancer, Recurrence, Hormonal receptor
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